Mechanisms of over-activated innate immune system regulation in autoimmune and neurodegenerative disorders.

摘要: Reactions of innate immunity include phagocytosis, the production and activity cytokines, chemokines, adhesion molecules, killing infected or changed cells by NK complement activated natural lectins, cytokine-dependent resistance leukocytes to viral infection. All these mechanisms maintain immunity. Deficiency in this is sometimes accompanied frequent bacterial infections. When permanently stimulated intensity reactions stronger, may be directed against host subsequently stimulate acquired (antibody cellular immunity). A higher oxidative stress, a high NO accompany autoimmunity neurodegeneration. The possible participation immune receptors, other factors development autoimmune neurodegenerative diseases discussed. importance role blood-derived microglial prevention elimination amyloid deposits plaque formation described. regulatory system, based on presence suppressors cytokine signaling (SOCS), receptors Tyro-3 family, adenosine phosphates, IL-10, reviewed. This review presents involved control response microglia disorders.