Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease
作者： A R Simard , S Rivest
关键词:
摘要: The role of innate immunity and microglia in the brain is currently a matter great debate controversy. While several studies have provided evidence that they contribute to neurodegeneration various animal models diseases traumas, others shown their inhibition may contrast be associated with more damages or less repair. We recently reported existence two different types microglia, resident newly differentiated derive from bone marrow stem cells. Of interest fact blood-derived microglial cells are amyloid plaques these able prevent formation eliminate presence deposits mice develop major hallmark Alzheimer's disease (AD). These recruited specifically attracted β-amyloid 40/42 isoforms vivo participate elimination proteins by phagocytosis. This review presents mechanisms involved control immune response beneficial properties such diseases, as AD.
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