Biological role of Toll-like receptor-4 in the brain.
作者： Teresa Trotta , Chiara Porro , Rosa Calvello , Maria Antonietta Panaro
DOI: 10.1016/J.JNEUROIM.2014.01.014
关键词:
摘要: The Toll-like receptors (TLRs) are a family of microbe-sensing that play central role in the regulation host immune system. TLR4 has been described brain and seems to regulate some physiological processes, such as neurogenesis. also reported during neurodegenerative disorders, including Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis Parkinson's disease. This review is focused on reports concerning recent insights into activation mechanisms brain, pathological conditions, well therapeutic benefit could derive from modulation.
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