Lysophosphatidic acid, a growth factor-like lipid, in the saliva

摘要: Lysophosphatidic acid is a multifunctional phos- pholipid mediator and elicits variety of biological re- sponses in vitro vivo. Evidence accumulating that lysophosphatidic plays important physiological roles diverse mammalian tissues cells. In the present study, we first examined whether human saliva. We found significant amount lyso- phosphatidic saliva (0.785 nmol/ml). The predominant fatty acyl moiety was 18:1n-9 � n-7 followed by 18:0 16:0. A small lysoplasmanic acid, an alkyl ether-linked analog also detected (0.104 physiologically relevant concen- trations induced accelerated growth cells mouth, pharynx, esophagus origin vitro. rapid increases intracellular free Ca 2 concentrations these ob- tained evidence receptor mRNAs are actually These results strongly suggest involved wound healing upper digestive organs such as esophagus. —Sugiura, T., S. Nakane, Kish- imoto, K. Waku, Y. Yoshioka, A. Tokumura. Lysophos- phatidic factor-like lipid, J. Lipid Res. 2002. 43: 2049-2055.