Contractile actions of lysophosphatidic acids with a chemically-defined fatty acyl group on longitudinal muscle from guinea-pig ileum.
作者： A. TOKUMURA , K. FUKUZAWA , H. TSUKATANI
DOI: 10.1111/J.2042-7158.1982.TB04776.X
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摘要: Various lysophosphatidic acids caused phasic contractions of longitudinal muscle from guinea-pig ileum, followed by rhythmical lower magnitude. Polyunsaturated were more potent than saturated acids. Among the tested, linolenoyl-lysophosphatidic acid was most active, but its activity about 3-5 times less that prostaglandin F2 alpha. Contractile responses to various acids, partially suppressed tetrodotoxin, atropine and chlorpheniramine. In addition, acid-induced considerably reduced pretreatment with indomethacin.
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