Primary HIV infection as source of HIV transmission within steady and casual partnerships among homosexual men.
作者： Maria Xiridou , Ronald Geskus , John de Wit , Roel Coutinho , Mirjam Kretzschmar
DOI: 10.1097/00002030-200406180-00010
关键词: Lentivirus 、 Demography 、 Transmission (mechanics) 、 Acquired immunodeficiency syndrome (AIDS) 、 Infectivity 、 Medicine 、 Casual 、 Sida 、 Immunology 、 Viral disease 、 Incidence (epidemiology)
摘要: Objective: To assess the contribution of primary or acute HIV infection to transmission among homosexual men in Amsterdam and investigate how initiation treatment during (PHI) can affect incidence infection. Methods: A mathematical model describing was developed. In model, are involved both steady casual partnerships. Infectivity is higher PHI than chronic Highly active antiretroviral therapy reduces infectivity increases time development AIDS. Its effect enhanced if initiated PHI. fraction attributed were calculated for different levels efficacy. Results: Primary infections account 35% transmissions from partners 6% partners. Among all new infections, only 11% occurs Therefore, on limited. However, a community with risky behaviour partners, 25%. Conclusion: play more important role communities which majority epidemic at an advanced phase, rather small early
core.ac.uk
narcis.nl
lww.com 参考文章(42)
Maria Dorrucci, Maria Balducci, Patrizio Pezzotti, Alessandro Sinicco, Francesco Alberici, Giovanni Rezza, Temporal changes in the rate of progression to death among Italians with known date of HIV seroconversion : Estimates of the population effect of treatment Journal of Acquired Immune Deficiency Syndromes. ,vol. 22, pp. 65- 70 ,(1999) , 10.1097/00042560-199909010-00008
Survival after introduction of HAART in people with known duration of HIV-1 infection. Lancet (British edition). ,vol. 355, pp. 1158- 1159 ,(2000) , 10.1016/S0140-6736(00)02069-9
Joseph J. Eron, Pietro L. Vernazza, David M. Johnston, Françoise Seillier-Moiseiwitsch, Timothy M. Alcorn, Susan A. Fiscus, Myron S. Cohen, Resistance of HIV-1 to antiretroviral agents in blood and seminal plasma: implications for transmission AIDS. ,vol. 12, ,(1998) , 10.1097/00002030-199815000-00003
Jean-Michel Tassie, Sophie Grabar, Rémi Lancar, Jacqueline Deloumeaux, Michèle Bentata, Dominique Costagliola, Clinical Epidemiology Group from the French Hospital Database on HIV, Time to AIDS from 1992 to 1999 in HIV-1-infected subjects with known date of infection. Journal of Acquired Immune Deficiency Syndromes. ,vol. 30, pp. 81- 87 ,(2002) , 10.1097/00042560-200205010-00011
Paulo F Barroso, Mauro Schechter, Phalguni Gupta, Maria F Melo, Marcello Vieira, Fernanda C Murta, Yeda Souza, Lee H Harrison, Effect of antiretroviral therapy on HIV shedding in semen. Annals of Internal Medicine. ,vol. 133, pp. 280- 284 ,(2000) , 10.7326/0003-4819-133-4-200008150-00012
Joel E. Gallant, Strategies for Long-term Success in the Treatment of HIV Infection JAMA. ,vol. 283, pp. 1329- 1334 ,(2000) , 10.1001/JAMA.283.10.1329
C. Pedersen, B. O. Lindhardt, B. L. Jensen, E. Lauritzen, J. Gerstoft, E. Dickmeiss, J. Gaub, E. Scheibel, T. Karlsmark, Clinical course of primary HIV infection: consequences for subsequent course of infection. BMJ. ,vol. 299, pp. 154- 157 ,(1989) , 10.1136/BMJ.299.6692.154
D. D. Ho, Toward HIV Eradication or Remission: The Tasks Ahead Science. ,vol. 280, pp. 1866- 1867 ,(1998) , 10.1126/SCIENCE.280.5371.1866
Ireneus P.M. Keet, Pieta Krijnen, Maarten Koot, Joep M.A. Lange, Frank Miedema, Jaap Goudsmit, Roel A. Coutinho, Predictors of Rapid Progression to AIDS in HIV-1 Seroconverters AIDS. ,vol. 7, pp. 51- 57 ,(1993) , 10.1097/00002030-199301000-00008
Matthew G. Law, Garrett Prestage, Andrew Grulich, Paul Van de Ven, Susan Kippax, Modelling the effect of combination antiretroviral treatments on HIV incidence. AIDS. ,vol. 15, pp. 1287- 1294 ,(2001) , 10.1097/00002030-200107060-00011