Bone marrow-derived antigen-presenting cells are required for the generation of cytotoxic T lymphocyte responses to viruses and use transporter associated with antigen presentation (TAP)-dependent and -independent pathways of antigen presentation.

摘要: Bone marrow (BM)-derived professional antigen-presenting cells (pAPCs) are required for the generation of cytotoxic T lymphocyte (CTL) responses to vaccinia virus and poliovirus. Furthermore, these BM-derived pAPCs require a functional transporter associated with antigen presentation (TAP). In this report we analyze requirements TAP in initiation CTL lymphocytic choriomeningitis (LCMV) influenza (Flu). Our results indicate requirement viruses. However, found that CTLs one LCMV epitope (LCMV nucleoprotein 396–404) was dependent on but, surprisingly, independent. The study response Flu confirmed existence pAPC-dependent/TAP-independent indicated TAP-independent pathway is ∼10–300-fold less efficient than TAP-dependent pathway.