Critical Roles of Tumorigenic and Migrating Cancer Stem/Progenitor Cells in Cancer Progression and their Therapeutic Implications

摘要: Recent progress in cancer stem/progenitor cell research has revealed that these poorly differentiated, multipotent, and malignant cells may provide critical functions for tumor formation, metastases, resistance to current clinical therapies, disease relapse. More specifically, the transformation of tissue-resident adult into tumorigenic migrating during progression, more particularly acquisition a migratory phenotype epithelial–mesenchymal transition (EMT) program, lead aggressive metastatic subtypes. The EMT process is generally associated with changes local microenvironment, niche cells, cell–cell detachment, remodeling stromal components including activation host myofibroblasts, immune cells. These molecular events result complex network oncogenic signaling pathways their differentiated progenies, initiating autocrine paracrine manners by diverse growth factors, cytokines, extracellular matrix progression. stimulation cascades contribute sustained growth, survival, migration, invasion, treatment On basis observations, it appears targeting represent new promising therapeutic strategy be exploited improve therapies against aggressive, metastatic, recurrent, lethal cancers.