Progressive demyelination and reparative phenomena in chronic experimental allergic encephalomyelitis.

摘要: Chronic experimental allergic encephalomyelitis (EAE), produced in inbred guinea pigs given a single inoculation during the juvenile period with isologous spinal cord complete Freund's adjuvant, has been studied by light and electron microscopy. Most animals showed delayed onset of nurologic signs from 12 to 68 weeks post-inoculation (PI), while several were asymptomatic up 74 PI. Two relapsing clinical course. Examination cords all revealed chronic demyelination, remyelination, recent demyelination. Marked perivascular inflammation, including plasma cells, was seen within demyelinated plaques. The usual type central nervous system (CNS) remyelination documented but addition, CNS axons invading Schwann cells noted. This cell invasion, not previously EAE, predominantly area root entry zone, occasionally involved extensive areas dorsal or ventral horns. extent as well CNS-type demonstrates reparative capacity CNS. recurrent morphologic changes these long-term provides further evidence that this model EAE many features reminiscent multiple sclerosis. underlying immunologic mechanisms responsible for disease are unknown. presence inflammatory exudates might suggest role B animals. possibility an intermittent release loculated adjuvant/antigen accounting considered.