Analysis of microRNAs in patients with systemic lupus erythematosus, using Solexa deep sequencing.
作者： Wenbiao Chen , Kuibi Tan , Jianrong Huang , Xiangqi Yu , Wujian Peng
DOI: 10.3109/03008207.2014.905548
关键词: Downregulation and upregulation 、 Lupus erythematosus 、 Gene 、 Gene expression profiling 、 Deep sequencing 、 Bioinformatics 、 In patient 、 Clone (cell biology) 、 Biology 、 microRNA
摘要: AbstractObjectives: Our aim in this study was to identify and examine the differential expression of microRNAs patients with systemic lupus erythematosus (SLE).Methods: We employed high-quality, high-throughput Solexa sequencing clone SLE a control group.Results: From data, we identified numerous displaying significantly different levels healthy controls. The 212 199 were upregulated downregulated, respectively. Only 61 novel exhibited two groups. target genes group found have cell metabolism functions. also analyzed chromosomal locations high level between A profile comparison revealed that majority transcripts expressed at similar level. functional classes most abundant microR...
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