Spiculisporic acid analogues of the marine-derived fungus, Aspergillus candidus strain HDf2, and their antibacterial activity.
作者： Rong Wang , Zhi Kai Guo , Xiang Min Li , Fu Xiao Chen , Xia Fei Zhan
DOI: 10.1007/S10482-015-0462-Y
关键词: Biochemistry 、 Spiculisporic acid 、 Aspergillus candidus 、 Fungus 、 Pathogen 、 Microbiology 、 Antibacterial activity 、 Biology 、 Staphylococcus aureus 、 Biological activity 、 Pseudomonas
摘要: Two novel antibiotic spiculisporic acid analogues, named as F (1) and G (2), two known compounds, (−)-spiculisporic (3) secospiculisporic B (4), were isolated by bioactivity-guided fractionation from the fermentation broth of sea urchin-derived Aspergillus candidus strain HDf2. Their structures unambiguously established comprehensive analysis 1D 2D NMR, high-resolution MS spectra, comparison with compounds. Biological experiments demonstrated that compounds 1 2 displayed antibacterial activity against Gram-negative Pseudomonas solanacearum Gram-positive Staphylococcus aureus, but showed no cytotoxicity SGC-7901 human gastric adenocarcinoma SPC-A-1 lung tumor cell lines. This is first critical evidence identifying derivatives a potential bio-control agent for soil borne pathogen P. (E. F. Smith) Smith. These findings provide further insight into chemical biological diversity this class
springer.com
sci-hub.se 参考文章(18)
M. A. Fischbach, C. T. Walsh, Antibiotics For Emerging Pathogens Science. ,vol. 325, pp. 1089- 1093 ,(2009) , 10.1126/SCIENCE.1176667
Peng Zhang, Attila Mándi, Xiao-Ming Li, Feng-Yu Du, Jia-Ning Wang, Xin Li, Tibor Kurtán, Bin-Gui Wang, Varioxepine A, a 3H-Oxepine-Containing Alkaloid with a New Oxa-Cage from the Marine Algal-Derived Endophytic Fungus Paecilomyces variotii Organic Letters. ,vol. 16, pp. 4834- 4837 ,(2014) , 10.1021/OL502329K
Jixing Peng, Huquan Gao, Jing Li, Jing Ai, Meiyu Geng, Guojian Zhang, Tianjiao Zhu, Qianqun Gu, Dehai Li, Prenylated indole diketopiperazines from the marine-derived fungus Aspergillus versicolor. Journal of Organic Chemistry. ,vol. 79, pp. 7895- 7904 ,(2014) , 10.1021/JO5010179
Zehong Wu, Dong Liu, Peter Proksch, Peng Guo, Wenhan Lin, Punctaporonins H-M: Caryophyllene-type sesquiterpenoids from the sponge-associated fungus Hansfordia sinuosae Marine Drugs. ,vol. 12, pp. 3904- 3916 ,(2014) , 10.3390/MD12073904
Rong Wang, Tian-Mi Liu, Ming-Hui Shen, Ming-Qiu Yang, Quan-Ying Feng, Xian-Ming Tang, Xiang-Min Li, Spiculisporic acids B–D, three new γ-butenolide derivatives from a sea urchin-derived fungus Aspergillus sp. HDf2. Molecules. ,vol. 17, pp. 13175- 13182 ,(2012) , 10.3390/MOLECULES171113175
Liat Koch, Anat Lodin, Inbal Herold, Micha Ilan, Shmuel Carmeli, Oded Yarden, Sensitivity of Neurospora crassa to a Marine-Derived Aspergillus tubingensis Anhydride Exhibiting Antifungal Activity That Is Mediated by the MAS1 Protein Marine Drugs. ,vol. 12, pp. 4713- 4731 ,(2014) , 10.3390/MD12094713
Sean P. Brown, Nicole C. Goodwin, David W. C. MacMillan, The First Enantioselective Organocatalytic Mukaiyama−Michael Reaction: A Direct Method for the Synthesis of Enantioenriched γ-Butenolide Architecture Journal of the American Chemical Society. ,vol. 125, pp. 1192- 1194 ,(2003) , 10.1021/JA029095Q
Jon Clardy, Michael A Fischbach, Christopher T Walsh, New antibiotics from bacterial natural products. Nature Biotechnology. ,vol. 24, pp. 1541- 1550 ,(2006) , 10.1038/NBT1266
Hee Shin, Hwa-Sun Lee, Jong Lee, Junho Shin, Min Lee, Hyi-Seung Lee, Yeon-Ju Lee, Jieun Yun, Jong Kang, Violapyrones H and I, new cytotoxic compounds isolated from Streptomyces sp. associated with the marine starfish Acanthaster planci. Marine Drugs. ,vol. 12, pp. 3283- 3291 ,(2014) , 10.3390/MD12063283
Faxiang Ji, Yuejun Zhang, Yutaka Ishigami, Spiculisporic acid. Functional development of biosurfactant Chimica Oggi-chemistry Today. ,vol. 18, pp. 32- 34 ,(2000)