Violapyrones H and I, new cytotoxic compounds isolated from Streptomyces sp. associated with the marine starfish Acanthaster planci.
作者： Hee Shin , Hwa-Sun Lee , Jong Lee , Junho Shin , Min Lee
DOI: 10.3390/MD12063283
关键词:
摘要: Two new α-pyrone derivatives, violapyrones H (1) and I (2), along with known B (3) C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived crown-of-thorns starfish, Acanthaster planci, collected Chuuk, Federated States Micronesia. structures elucidated by analysis 1D 2D NMR HR-ESIMS data. Violapyrones (1–4) exhibited cytotoxicity against 10 human cancer cell lines GI50 values 1.10–26.12 μg/mL when tested using sulforhodamine (SRB) assay. This is first report on absolute configuration violapyrone C.
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