SPARC is associated with carcinogenesis of oral squamous epithelium and consistent with cell competition
作者： Tomohiro Yamada , Seiji Ohno , Naoya Kitamura , Eri Sasabe , Tetsuya Yamamoto
DOI: 10.1007/S00795-014-0089-5
关键词: Epithelium 、 Pathology 、 Mouth neoplasm 、 Cell 、 Cell growth 、 Osteonectin 、 Leukoplakia 、 Carcinogenesis 、 Biology 、 Matricellular protein
摘要: The matricellular protein, secreted protein acidic and rich in cysteine (SPARC) is thought to be involved cell competition. objective of this study investigate the role SPARC cancerization oral squamous epithelium. Clinical specimens from 57 pre- early cancerous lesion, 66 invasive carcinoma (SCC) controls were immunostained with SPARC. features expression evaluated. Furthermore, effects knockdown overexpression examined cancer keratinocyte lines. Leukoplakia, situ, SCC had more SPARC-positive cells than normal mucous However, there no significant differences between leukoplakia, SCC, correlations immunoreactivity prognosis SCCs. Cell proliferation was down-regulated by siRNA, enhanced transformed keratinocytes. But did not enhance migration activity. induced dysplastic stage cancerization, may improve survival capability, but malignancy. act escape elimination
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