Apoptotic signaling in salivary mucoepidermoid carcinoma.
作者： Gabriela M da Silva , Victoria Saavedra , Renata CF Ianez , Elen A de Sousa , Ágatha N Gomes
DOI: 10.1002/HED.25763
关键词:
摘要: BACKGROUND Mucoepidermoid carcinoma is the most common malignant tumor of salivary glands. Apoptosis plays an important role in organogenesis glandular structures, and aberrations apoptotic mechanisms associated with a wide array pathologic conditions. METHODS The immunoexpression proteins apoptosis proliferation was evaluated 40 mucoepidermoid cases. RESULTS Par-4, Survivin, MUC1, PHLDA1, Fas, Ki-67 were predominantly expressed carcinoma. FasL rarely expressed, Caspase-3 expression observed almost 50% SPARC low-grade tumors, lymph node metastasis. Expression Fas decreased better overall cancer-specific survival rates. CONCLUSIONS association pathological features Caspase-3, probabilities suggest that these may be useful prognostic markers for
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