Effects of cyclosporin-A on immune response, tissue protection and motor function of rats subjected to spinal cord injury
作者： Antonio Ibarra , Dolores Correa , Kaethe Willms , Marie Therese Merchant , Gabriel Guı́zar-Sahagún
DOI: 10.1016/S0006-8993(03)02898-1
关键词: Spinal cord compression 、 Paraplegia 、 Lesion 、 Central nervous system 、 Spinal cord injury 、 Anesthesia 、 Cyclosporin a 、 Spinal cord 、 Pathology 、 Neuroprotection 、 Medicine
摘要: The aim of this work was to test the effect cyclosporin-A (CsA) on some immunological, morphological and functional aspects developed after spinal cord injury. specific cellular immune response against constituents, amount spared tissue myelination at site injury, motor function outcome were assessed in a first series experiments. Rats subjected compression treated with before lesion during entire study. A lymphocyte antigens found untreated injured rats but not cyclosporine-A rats. significantly better index also cyclosporin-A-treated rats, as compared animals. epicenter different comparing CsA-treated vehicle-treated Looking for potential therapeutic use CsA, second experiments, contusion from 1 72 h lesion. Motor recovery red nuclei neurons survival, evaluated, be than injured-untreated This confirms existence an autoimmune reaction injury that can inhibited by treatment. Furthermore, promotes neuroprotection diminishing both demyelination neuronal cell death, resulting
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