Relationship between three novel SNPs of BRCA1 and canine mammary tumors.
作者： Weidong Sun , Xu Yang , Hengbin Qiu , Di Zhang , Huanan Wang
DOI: 10.1292/JVMS.15-0044
关键词: Polymorphism (computer science) 、 Genetics 、 Single-nucleotide polymorphism 、 Exon 、 Genetic variation 、 Rapid amplification of cDNA ends 、 Odds ratio 、 Cancer 、 SNP 、 Molecular biology 、 Biology
摘要: The BRCA1 gene plays an important role in the development of human breast cancer, and recent research indicated that genetic variations of BRCA1 are also related to canine mammary tumors (CMTs). Here, using rapid amplification of cDNA ends (RACE), we cloned the 5′-and 3′-UTRs of BRCA1. By direct sequencing of the flanking sequences of the 5′-and 3′-UTRs of BRCA1, three previously unreported single-nucleotide polymorphisms (SNPs) were identified, two (− 1228T> C,− 1173C> T) in the putative promoter regions and …
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