The BRCA1 3'-UTR: 5711+421T/T_5711+1286T/T genotype is a possible breast and ovarian cancer risk factor.
作者： Malinee Pongsavee , Vichanan Yamkamon , Sumana Dakeng , Pornchai O-Charoenrat , Duncan R. Smith
关键词: SNP array 、 Genotype 、 Single-nucleotide polymorphism 、 Breast cancer 、 Allele 、 Untranslated region 、 Biology 、 Cancer 、 Allele frequency 、 Cancer research 、 Genetics
摘要: Background: A significant proportion of familial and early-onset breast ovarian cancers occur in individuals without coding mutations BRCA1 BRCA2. Aims: We identified genetic variation at 3′-untranslated region (UTR) cancer patients both with BRCA1/2 mutation the regions (BRCA1/2 pos neg), verified possible risk factor specific 3′-UTR using functional analysis. Methods: SNP analysis was screened 46 103 unaffected Thais by heteroduplex DNA sequencing. After chi-square test for potential association genotypes, tests were conducted several strategies luciferase gene expression model. Results: document existence two polymorphic sites, 5711+421(G or T) 5711+1286(C T). Frequency homozygous genotype 5711+421T/T_5711+1286T/T (or T/T-T/T) group of...
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