NMR metabolomics and drug discovery
作者： Robert Powers
DOI: 10.1002/MRC.2461
关键词: Nmr based metabolomics 、 Chemistry 、 Disease biomarker 、 Drug toxicity 、 Pharmacology 、 Drug discovery 、 Metabolomics 、 Computational biology
摘要: NMR is an integral component of the drug discovery process with applications in lead discovery, validation, and optimization. routinely used for fragment-based ligand affinity screens, high-resolution protein structure determination, rapid protein-ligand co-structure modeling. Because this inherent versatility, currently making significant contributions burgeoning area metabolomics, where successfully being to identify biomarkers various diseases, analyze toxicity determine a drug's vivo efficacy selectivity. This review describes advances NMR-based metabolomics discusses some recent applications. Copyright © 2009 John Wiley & Sons, Ltd.
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