Trafficking the NGF signal: implications for normal and degenerating neurons.
作者： Jean-Dominique Delcroix , Janice Valletta , Chenbiao Wu , Charles L. Howe , Chun-Fai Lai
DOI: 10.1016/S0079-6123(03)46001-9
关键词: Signal transduction 、 Endocytic vesicle 、 Neuroscience 、 Tropomyosin receptor kinase A 、 Neuron 、 Axoplasmic transport 、 Nerve growth factor 、 Biology 、 Axon 、 Endosome
摘要: Nerve growth factor (NGF) activates TrkA to trigger signaling events that promote the survival, differentiation and maintenance of neurons. The mechanism(s) controls retrograde transport NGF signal from axon terminals neuron cell bodies is not known. 'signaling endosome' hypothesis stipulates NGF, proteins are retrogradely transported on endocytic vesicles. Here, we provide evidence for existence endosomes. Following treatment, clathrin-coated vesicles (CCVs) contain bound together with activated Ras/pErk1/2 pathway. signals isolated CCVs through Erk1/2 Early endosomes appear represent a second type We found induced sustained activation Rap1, small monomeric GTP-binding protein Ras family, this occurred in early key elements Rap1/pErk1/2 discuss possibility failure mouse model Down syndrome (Ts65Dn) may be due It important define further significance biology both normal degenerating
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