STAT3‑regulated long non‑coding RNAs lnc‑7SK and lnc‑IGF2‑AS promote hepatitis C virus replication

摘要: Long non-coding RNAs (lncRNAs) are a class of that do not code protein but important in diverse biological processes. In previous years, with the application high-throughput sequencing, large number lncRNAs associated virus infections have been identified and intensively investigated, however, there few studies examining association between HCV replication. Previous demonstrated signal transducer activator transcription 3 (STAT3) is activated by hepatitis C (HCV) turn increases replication HCV. However, detailed molecular mechanism only partially understood. present study, using human lncRNA polymerase chain reaction (PCR) arrays, it was lnc-IGF2-AS, lnc-7SK, lnc-SChLAP1 lnc-SRA1 upregulated STAT3. addition, among these four lncRNAs, lnc-IGF2-AS lnc-7SK were involved Transfection siRNA inhibited Huh7 cells. Data also indicated when transfected expression phosphatidylinositol 4-phosphate (PI4P), which to be replication, reduced. Thus, study two new types can STAT3 regulating PI4P.