Insight Into the Role of Long Noncoding RNA in Cancer Development and Progression.

摘要: Long noncoding RNA (LncRNA) is a large class of molecules with size larger than 200 nucleotides. They exhibit cellular functions although having no protein-coding capability. Accumulating evidence suggests that long play crucial roles in cancer biology. Studies showed deregulation lncRNA was frequently observed various types cancers which contributed heavily to malignant phenotypical changes. Aberration can be induced by number factors such as dysregulated signaling pathway, response catastrophic effect, viral infection, and contact carcinogens. Meanwhile, alterations expression or function drive subsequent development cell transformation acquisition stemness characteristics. Here, we give perspectives on recent findings the involvement lncRNAs carcinogenesis adverse tumor environment. Then, discuss role stem an important model emergence. Last, provide insight potential modulating environment favorable progression, evaluate diagnostic prognostic value management.