Long Noncoding RNA CUDR Regulates HULC and β-Catenin to Govern Human Liver Stem Cell Malignant Differentiation

作者: Xin Gui , Haiyan Li , Tianming Li , Hu Pu , Dongdong Lu

DOI: 10.1038/MT.2015.166

关键词:

摘要: Long noncoding RNA cancer upregulated drug resistant (CUDR) is overexpressed in many tumors and promotes tumorigenesis. Herein, we demonstrate CUDR could enhance the human embryonic stem cells (ESC) differentiation into hepatocyte-like by reducing trimethylation on histone H3 twenty-seventh lysine (H3K27me3). On other hand, excessive triggers malignant transformation. Mechanistically, identify causes highly liver (HULC) β-catenin abnormal expression inhibiting HULC promoter methylation promoting promoter-enhancer chromatin looping formation mediated CUDR-ccctc-binding factor (CTCF) complex, which recruits more polII P300. Strikingly, activity are crucial for oncogenic function. These findings provide first demonstration that plays a positive potential role cell through cascade of CUDR-HULC/CUDR-β-catenin signaling, offer insights novel link between long (lncRNA) epigenetic modification cells.

参考文章(41)
Laurence Pibouin, Jacqueline Villaudy, Didier Ferbus, Martine Muleris, Marie-Thérèse Prospéri, Yurgos Remvikos, Gérard Goubin, Cloning of the mRNA of overexpression in colon carcinoma-1 Cancer Genetics and Cytogenetics. ,vol. 133, pp. 55- 60 ,(2002) , 10.1016/S0165-4608(01)00634-3
Jessamy C. Tiffen, Charles G. Bailey, Amy D. Marshall, Cynthia Metierre, Yue Feng, Qian Wang, Sarah L. Watson, Jeff Holst, John E.J. Rasko, The cancer-testis antigen BORIS phenocopies the tumor suppressor CTCF in normal and neoplastic cells International Journal of Cancer. ,vol. 133, pp. 1603- 1613 ,(2013) , 10.1002/IJC.28184
Zhong Deng, Zhuo Wang, Nick Stong, Robert Plasschaert, Aliah Moczan, Horng-Shen Chen, Sufeng Hu, Priyankara Wikramasinghe, Ramana V Davuluri, Marisa S Bartolomei, Harold Riethman, Paul M Lieberman, A role for CTCF and cohesin in subtelomere chromatin organization, TERRA transcription, and telomere end protection. The EMBO Journal. ,vol. 31, pp. 4165- 4178 ,(2012) , 10.1038/EMBOJ.2012.266
Stephen Meek, Jun Wei, Linda Sutherland, Benedikt Nilges, Mia Buehr, Simon R. Tomlinson, Alison J. Thomson, Tom Burdon, Tuning of β‐catenin activity is required to stabilize self‐renewal of rat embryonic stem cells Stem Cells. ,vol. 31, pp. 2104- 2115 ,(2013) , 10.1002/STEM.1466
Moshe Yaniv, Lionel Gresh, Günther Schütz, Jacqueline Barra, François Tronche, Charles Babinet, Laurence Fiette, Marco Pontoglio, Catherine Coffinier, Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1β Development. ,vol. 129, pp. 1829- 1838 ,(2002) , 10.1242/DEV.129.8.1829
Lu Cao, Yanming Zhou, Beibei Zhai, Jian Liao, Wen Xu, Ruixiu Zhang, Jing Li, Yu Zhang, Lei Chen, Haihua Qian, Mengchao Wu, Zhengfeng Yin, Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines BMC Gastroenterology. ,vol. 11, pp. 71- 71 ,(2011) , 10.1186/1471-230X-11-71
H. Kubota, L. M. Reid, Clonogenic hepatoblasts, common precursors for hepatocytic and biliary lineages, are lacking classical major histocompatibility complex class I antigen Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 12132- 12137 ,(2000) , 10.1073/PNAS.97.22.12132
Samantha E. Hiemer, Aleksander D. Szymaniak, Xaralabos Varelas, The transcriptional regulators TAZ and YAP direct transforming growth factor β-induced tumorigenic phenotypes in breast cancer cells. Journal of Biological Chemistry. ,vol. 289, pp. 13461- 13474 ,(2014) , 10.1074/JBC.M113.529115
Yu Fan, Bing Shen, Mingyue Tan, Xinyu Mu, Yan Qin, Fang Zhang, Yong Liu, Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling. FEBS Journal. ,vol. 281, pp. 1750- 1758 ,(2014) , 10.1111/FEBS.12737
Xuefei Shi, Ming Sun, Hongbing Liu, Yanwen Yao, Yong Song, Long non-coding RNAs: A new frontier in the study of human diseases Cancer Letters. ,vol. 339, pp. 159- 166 ,(2013) , 10.1016/J.CANLET.2013.06.013