Expression pattern of genes in peripheral blood mononuclear cells in diabetic nephropathy.
作者： DK Moczulski , H Fojcik , A Wielgorecki , W Trautsolt , B Gawlik
DOI: 10.1111/J.1464-5491.2006.02067.X
关键词: Medicine 、 Genetic predisposition 、 Diabetic nephropathy 、 Proteinuria 、 Internal medicine 、 Immunology 、 Type 1 diabetes 、 Kidney disease 、 Diabetes mellitus 、 Endocrinology 、 Peripheral blood mononuclear cell 、 Candidate gene
摘要: Aims Only one-third of Type 1 diabetes patients develop diabetic nephropathy, and a genetic predisposition is postulated. To obtain more insight into processes that lead to messenger RNA expression profiles peripheral blood mononuclear cells from with without nephropathy were compared. Methods We studied seven male proteinuria 12 normoalbuminuria after at least 20 years duration. The genes was examined using the microarray method Human Genome U133A Arrays (Affymetrix, Santa Clara, CA, USA). analysed all candidate suggested be involved in pathogenesis previously published articles. Altogether, 198 genes analysed. Results found thrombospondin 1 (THBS1) cyclooxygenase 1 (COX1) over-expressed matrix metalloproteinase 9 (MMP9) cyclooxygenase 2 (COX2) had lower nephropathy. For other genes, we did not observe different between or too low for analysis. Conclusions gene pattern might indicate an important pathway this complication.
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