Red ginseng extract protects against carbon tetrachloride-induced liver fibrosis.

摘要: Korean red ginseng, the processed root of Panax ginseng Meyer, has been frequently used for various therapeutic purposes in oriental medicine. The present study investigated possible effect extract (RGE) treatment liver fibrosis mice injected with carbon tetrachloride (CCl4) 4 wk. Liver injuries were assessed by blood biochemistry and histopathology treated CCl4 alone or CCl4+ RGE (30, 100, 300 mg/kg). Concomitant (three times/wk wk) effectively inhibited as evidenced decreases plasma alanine aspartate aminotransferases, well percentages degenerative regions, numbers hepatocytes, collagen accumulation hepatic parenchyma. Treatment wk increased mRNA levels transforming growth factor b1 plasminogen activator inhibitor 1 fibrogenic liver, whereas mg/kg) significantly blocked induction genes CCl4. Similarly, also prevented b1-mediated human stellate cell lines. More importantly, markedly reduced number a-smooth muscle actin-positive cells tissue. This implies that efficaciously protects against induced chronic treatment, may therefore have potential to treat disease.