Schisandrae Fructus Supplementation Ameliorates Sciatic Neurectomy-Induced Muscle Atrophy in Mice

摘要: The objective of this study was to assess the possible beneficial skeletal muscle preserving effects ethanol extract Schisandrae Fructus (EESF) on sciatic neurectomy- (NTX-) induced hindlimb atrophy in mice. Here, calf by unilateral right NTX. In order investigate whether administration EESF prevents or improves NTX-induced atrophy, administered orally. Our results indicated that dose-dependently diminished decreases markers mass and activity levels, increases damage fibrosis, inflammatory cell infiltration, cytokines, apoptotic events gastrocnemius bundles are Additionally, destruction antioxidant defense systems after NTX protected treatment with EESF. also upregulated muscle-specific mRNAs involved protein synthesis but downregulated those degradation. overall 500 mg/kg were similar 50 mg/kg oxymetholone, it showed more favorable effects. present suggested exerts a ameliorating effect NTX, through anti-inflammatory related fiber protective via an increase decrease