Impaired hydrogen metabolism in pneumatosis cystoides intestinalis

摘要: Abstract Background: Pneumatosis cystoides intestinalis (PCI) is characterized by high levels of breath hydrogen. Clinical features PCI may be due to abnormal H 2 metabolism. Methods: Breath and CH 4 were measured in 3 patients total gas with on a polysaccharide-free (basal) diet after administration 15 g lactulose. Metabolic activities counts methanogenic (MB) sulfate-reducing (SRB) bacteria feces. Ten volunteers also studied. Results: Total 383–420 mL/day the basal 1430–1730 lactulose compared 35 ± 6 262 65 mL/day, respectively, controls. Basal controls 27 vs. 214 ingestion, 115 18 370 72 mL/ day. Four had fecal MB counts. The other SRB sulfate reduction rates. All nonmethanogenic low Conclusions: Patients excrete more than In normal subjects, consumed or SRB; activity these virtually absent PCI. This explain accumulation patients.