In vivo monitoring of rat macrophages labeled with poly(l-lysine)-iron oxide nanoparticles.

摘要: Coprecipitation of FeCl2 and FeCl3 with aqueous ammonia was used to prepare iron oxide nanoparticles dispersible in medium. Oxidation the particles sodium hypochlorite then yielded maghemite (γ-Fe2O3) which were coated two types coating –d-mannose or poly(l-lysine) (PLL) as confirmed by FTIR analysis. The <10 nm according transmission electron microscopy. Their hydrodynamic particle size ∼180 (by dynamic light scattering). d-mannose-, PLL-coated, neat γ-Fe2O3 well commercial Resovist® label rat macrophages. viability contrast properties labeled macrophages compared. PLL-coated found optimal. injected rats monitored vivo magnetic resonance imaging up 48 h. Transport PLL-γ-Fe2O3 confirmed. Tracking using developed can be for monitoring inflammations cell migration therapy. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1141–1148, 2015.