Acceleration of norepinephrine synthesis in the rat submaxillary gland during sympathetic nerve stimulation
作者： Göran C. Sedvall , Irwin J. Kopin
DOI: 10.1016/0024-3205(67)90360-8
关键词: Tyrosine hydroxylase 、 In vivo 、 Norepinephrine (medication) 、 Endocrinology 、 Tyrosine 、 Stimulation 、 Endogeny 、 Tyrosine transport 、 Adrenergic 、 Chemistry 、 Internal medicine 、 General Pharmacology, Toxicology and Pharmaceutics 、 General Biochemistry, Genetics and Molecular Biology 、 General Medicine
摘要: Abstract In nembutal-anesthetized rats, the sympathetic nerves to submaxillary gland were stimulated electrically during simultaneous intravenous infusion of tyrosine-C14 and dopa-H3. Stimulation resulted in a four- five-fold increase norepinephrine synthesis from but not Endogenous content tyrosine specific activity significantly altered. The results suggest an impulse-induced acceleration adrenergic neurone. Synthesis is apparently at or before hydroxylation step, although there are no changes hydroxylase. rate might be controlled by transport, product inhibition, endogenous inhibitors cofactors
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