New insights on the pathomechanisms of inflammatory bowel disease.
作者： Murdani Abdullah , Ari Fahrial Syam , Marcellus Simadibrata , Jeffri Gunawan , Dadang Makmun
关键词: Inflammatory bowel disease 、 Disease 、 Medicine 、 Immunology 、 Inflammatory Bowel Diseases 、 Immune system 、 Pathogenesis 、 Microbiome
摘要: Pathogenesis of inflammatory bowel disease (IBD) remains an enigma on whether germs, genes or a combination these two with excessive immune responses to gut-associated bacteria explicates its pathomechanisms. The incidence IBD is 0.76747 per 100 000 in Central Indonesia, as shown the Project Indonesian ACCESS 2012 progress report. This result, together other epidemiological studies Asia, may conclusively reflect increased rates disease, while pathogenesis still undoubtedly obscured. However, knowledge pathophysiology rapidly growing, abreast new developments. A series recent updates core pathomechanisms such bacterial, endoplasmic reticulum stress, cell populations, T-cell differentiation and function, mucosal defenses oxidative stress are relevant pathomechanism keypoints IBD.
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