Microarchitecture of the Augmented Bone Following Sinus Elevation with an Albumin Impregnated Demineralized Freeze-Dried Bone Allograft (BoneAlbumin) versus Anorganic Bovine Bone Mineral: A Randomized Prospective Clinical, Histomorphometric, and Micro-Computed Tomography Study

摘要: Serum albumin has been identified as an endogenous protein that is integral to early bone regeneration. We hypothesized addition allografts may result in better remodeling than what can be achieved with anorganic xenografts. Sinus elevations were performed at 32 sites of 18 patients the lateral window technique. Sites either received filling bovine mineral (ABBM, BioOss, Geistlich, CH) or impregnated allograft (BoneAlbumin, OrthoSera, AT). After 6-months dental implants and 16 core biopsy samples obtained from ABBM filled, BoneAlbumin augmented sites. The biopsies examined by histomorphometry µCT. Percentage residual graft group was 0–12.7%, median 5.4% vs. 6.3–35.9%, 16.9%, p < 0.05. Results µCT analysis showed microarchitecture resembles native maxilla morphometric parameters Trabecular Pattern Factor Connectivity. Our data show while successfully integrates into newly formed tissue persisting particles, underway towards complete new closely resembling intact maxilla.