Efficient H/D Exchange Reactions of Alkyl‐Substituted Benzene Derivatives by Means of the Pd/C–H2–D2O System
作者： Hiroyoshi Esaki , Fumiyo Aoki , Miho Umemura , Masatsugu Kato , Tomohiro Maegawa
关键词: Ether 、 Heterogeneous catalysis 、 Moiety 、 Chemistry 、 Medicinal chemistry 、 Alkyl 、 Catalysis 、 Ring (chemistry) 、 Organic chemistry 、 Amide 、 Benzene
摘要: A method for efficient and extensive H/D exchange of substituted benzene derivatives which is catalyzed by heterogeneous Pd/C in D(2)O as a deuterium source under hydrogen atmosphere described. Multi-deuterium incorporation into unactivated linear or branched alkyl chains that bear carboxyl, hydroxyl, ether, ester, amide moiety are connected with ring was achieved using the Pd/C-H(2)-D(2)O system. The present does not require expensive gas any special equipment.
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