Serological distinciton of heavy chain variable regions (VH subgroups) of mouse immunoglobulins. I. Common VH determinants on the heavy chains of mouse myeloma proteins having different binding sites.

摘要: 16 of more than 100 mouse myeloma proteins, including 3 proteins the IgG2a class and 13 IgA class, were shown to have a similar heavy chain variable region (VH) antigen(s) (U10-173). The bearing these antigenic determinants (U10-173+ proteins) represented at least five different ligand-binding specificities. These findings, taken togeter with available sequence data for VH regions U10-173+ led us conclude that U10-173 defines small number related subgroups. ability detect subgroups in mice by serological means, as has been done humans also, promises new useful kinds markers immunologic study.