Effect of verapamil on renal haemodynamics in a portal hypertensive rat model.
作者： CHII-SHYAN LAY , MAY CHUEN-MAY YANG , SUE-LIN WU , YANG-TE TSAI , KUO-LIANG WU
DOI: 10.1111/J.1440-1746.1996.TB01389.X
关键词: Internal medicine 、 Kidney 、 Endocrinology 、 Mean arterial pressure 、 Cardiology 、 Hemodynamics 、 Portal venous pressure 、 Medicine 、 Vascular resistance 、 Verapamil 、 Portal hypertension 、 Renal blood flow
摘要: In order to investigate the effects of verapamil on renal haemodynamics in rats with portal hypertension, was given at either a low (0.2 mg/kg) or high (2 dose after vein ligation. An approximate 12% decrease mean arterial pressure followed administration verapamil, significant cardiac output and blood flow, as well reduced pressure, observed; these signs were all indicative rise vascular resistance. contrast, marked fall both accompanied by no change suggests reduction This study shows that acute may vary used. Also, tends flow alter autoregulation kidney; thus, caution should be taken clinical use treatment cirrhosis hypertension.
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