Lipids, lipoproteins, lifestyle, adiposity and fat-free mass during middle age: the Fels Longitudinal Study.

摘要: Although lipid profiles tend to worsen with age, it is not fully known if such age-related changes are influenced primarily by body composition and lifestyle or other aspects of aging. We investigated the extent which fat fat-free components mass index (BMI) factors influence patterns change in lipids independent age. Serial data were analyzed using sex-specific longitudinal models. These models use serial from individuals assume a general pattern over time, while allowing baseline age rate vary among individuals. obtained 940 examinations 269 healthy white participants (126 men, 143 women), aged 40–60 years, Fels Longitudinal Study. Measurements included (FMI) (FFMI) BMI, high-density lipoprotein (HDL-C), low-density (LDL-C), triglycerides (TG), total cholesterol (TC), fasting glucose insulin, physical activity, alcohol smoking, women's menopausal status estrogen use. In both sexes, increased FMI was significantly associated LDL-C, TG TC, decreased HDL-C. Increased FFMI related HDL-C TG. Independent effects remained significant only for LDL-C TC men women. insulin Moderate consumption higher men. Physical activity lowered male levels, female levels. Menopause increases LDL-C. Premenopausal women had lower HDL-C, TG, than postmenopausal taking estrogen. (1) Age an important predictor women, but as influential on (2) Increasing major contributor elevated levels (3) influences HDL sexes. (4) Maintaining BMI via reduced component may be more beneficial lowering CVD risks factors.