Carboxymethyl high amylose starch (CM-HAS) as excipient for Escherichia coli oral formulations.
作者： Mircea Alexandru Mateescu , Carmen Calinescu , Jérôme Mulhbacher , Éric Nadeau , John Morris Fairbrother
DOI: 10.1016/J.EJPB.2004.12.006
关键词: Escherichia coli 、 Dosage form 、 Drug delivery 、 Excipient 、 Amylose 、 Bacteria 、 Chemistry 、 Starch 、 Biochemistry 、 Enzymatic hydrolysis 、 Chromatography
摘要: Carboxymethyl high amylose starch (CM-HAS) is proposed as a novel excipient for oral tablet formulation of bioactive agents ensuring their protection in the stomach and delivery intestine. Three variants CM-HAS, with different degrees substitution, were synthesized by treatment various amounts monochloroacetic acid. The products dried powder form tablets obtained direct compression mixed powders polymeric lyophilized Escherichia coli (E. coli) bacteria. Dosage forms CM-HAS are unswollen compact acidic medium, active against acidity. Release bacteria from based on fast swelling during passage gastric acidity to alkaline intestinal enzymatic hydrolysis triggering rapid, almost total dissolution. thus formulated displayed higher survival rates conditions longer periods than free or non-derivatized starch. selected matrix also assured good viability after 6 months under refrigeration.
elsevier.com
sci-hub.se 参考文章(23)
J. H. Eldridge, R. M. Gilley, J. K. Staas, Z. Moldoveanu, J. A. Meulbroek, T. R. Tice, Biodegradable microspheres: vaccine delivery system for oral immunization. Current Topics in Microbiology and Immunology. ,vol. 146, pp. 59- 66 ,(1989) , 10.1007/978-3-642-74529-4_6
G. W. Jones, J. M. Rutter, Role of the K88 Antigen in the Pathogenesis of Neonatal Diarrhea Caused by Escherichia coli in Piglets Infection and Immunity. ,vol. 6, pp. 918- 927 ,(1972) , 10.1128/IAI.6.6.918-927.1972
H.U. Bertschinger, M. Bachmann, C. Mettler, A. Pospischil, E.M. Schraner, M. Stamm, T. Sydler, P. Wild, Adhesive fimbriae produced in vivo by Escherichia coli O139:K12(B):H1 associated with enterotoxaemia in pigs. Veterinary Microbiology. ,vol. 25, pp. 267- 281 ,(1990) , 10.1016/0378-1135(90)90083-8
Myron M. Levine, Escherichia coliInfections New England Journal of Medicine. ,vol. 313, pp. 445- 447 ,(1985) , 10.1056/NEJM198508153130710
Robert Edelman, Robert G. Russell, Genevieve Losonsky, Ben D. Tall, Carol O. Tacket, Myron M. Levine, Danny H. Lewis, Immunization of rabbits with enterotoxigenic E. coli colonization factor antigen (CFA/I) encapsulated in biodegradable microspheres of poly (lactide-co-glycolide). Vaccine. ,vol. 11, pp. 155- 158 ,(1993) , 10.1016/0264-410X(93)90012-M
C Chebli, L Cartilier, Effect of some physical parameters on the sustained drug-release properties of substituted amylose matrices. International Journal of Pharmaceutics. ,vol. 193, pp. 167- 173 ,(2000) , 10.1016/S0378-5173(99)00332-4
Jérôme Mulhbacher, Pompilia Ispas-Szabo, Vincent Lenaerts, Mircea Alexandru Mateescu, Cross-linked high amylose starch derivatives as matrices for controlled release of high drug loadings. Journal of Controlled Release. ,vol. 76, pp. 51- 58 ,(2001) , 10.1016/S0168-3659(01)00425-4
A.T.J. Bianchi, J-W. Scholten, A.M. van Zijderveld, F.G. van Zijderveld, B.A. Bokhout, Parenteral vaccination of mice and piglets with F4+ Escherichia coli suppresses the enteric anti-F4 response upon oral infection. Vaccine. ,vol. 14, pp. 199- 206 ,(1996) , 10.1016/0264-410X(95)00192-4
Jonathan L. Bundy, Catherine Fenselau, Lectin and Carbohydrate Affinity Capture Surfaces for Mass Spectrometric Analysis of Microorganisms Analytical Chemistry. ,vol. 73, pp. 751- 757 ,(2001) , 10.1021/AC0011639
Joseph Kost, Shmuel Shefer, Chemically-modified polysaccharides for enzymatically-controlled oral drug delivery Biomaterials. ,vol. 11, pp. 695- 698 ,(1990) , 10.1016/0142-9612(90)90029-P