Effect of some physical parameters on the sustained drug-release properties of substituted amylose matrices.
作者： C Chebli , L Cartilier
DOI: 10.1016/S0378-5173(99)00332-4
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摘要: Substituted amylose (SA) matrix drug tablets prepared by direct compression show sustained drug-release properties. The influence of force (CF) and tablet weight (TW) on release properties was studied. CF ranging from 0.5 to 5.0 tons/cm2 has no significant effect the SA,G (glycidol) polymers, with a degree substitution (DS) greater than 1.5. For low DS, an augmentation increases time acetaminophen, used as model drug, until certain limit is reached. On other hand, TW major acetaminophen. Release directly proportional TW. nature active material, its solubility concentration in formulation polymers also evaluated, demonstrating versatility system.
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