Spontaneous intra-uterine growth restriction modulates the endocrine status and the developmental expression of genes in porcine fetal and neonatal adipose tissue
作者： Florence Gondret , Marie-Christine Père , Sandrine Tacher , Sophie Daré , Christine Trefeu
DOI: 10.1016/J.YGCEN.2013.09.018
关键词: Insulin receptor 、 Hormone 、 Endocrinology 、 Internal medicine 、 GLUT4 、 Fetus 、 Biology 、 Adipose tissue 、 Low birth weight 、 Adipocyte 、 Insulin
摘要: Low birth weight is correlated with low adiposity at birth, a phenotype that influences neonatal survival and later adiposity. A better understanding of events affecting the fetal adipose tissue development its functionality around thus needed. This study was undertaken to examine impact spontaneous intra-uterine growth restriction (IUGR) on circulating concentrations hormones nutrients together developmental expression patterns various genes in subcutaneous pig fetus during last third pregnancy just after birth. At 71 112 days post-conception 2 postnatal, pairs same-sex piglets were chosen within litters have either medium (MBW) or (LBW) (n=6 each stage). The results indicate IUGR counteracts temporal fall DLK1 gene developing across gestation. It also attenuates time-dependent increase levels many promoting adipocyte differentiation (PPARG, CEBPA) lipogenesis (LPL, SREBF1, FASN, FABP4). Opposite responses observed for IGF system, so IGF1 mRNA lower (P<0.001) but IGF2 greater LBW compared MBW piglets. plasma insulin concentration receptor (INSR) insulin-responsive glucose transporter (GLUT4) day postnatal. data delays normal ontogeny gestation affects axes
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