The circadian clock component PERIOD2: from molecular to cerebral functions.

摘要: Abstract The circadian clock is based on a molecular oscillator, which simulates the external day within nearly all of body's cells. This “internalized” then defines activity and rest phases for cells organism by generating precise rhythms in metabolism, physiology, behavior. In its perfect state, this timing system allows synchronization an to environment may optimize energy handling responses daily recurring challenges. However, nowadays, we believe that desynchronization due lifestyle or problems with not only causes discomfort but also aggravate conditions such as depression, metabolic syndrome, addiction, cancer. review, focus one simple cogwheel mammalian clock, PERIOD2 (PER2) protein. Originally identified integral part mechanism yields overt about 24 h, more recently multiple other functions have been identified. essence, PER proteins, addition their important function can be seen integrators input side mediators output. diversity possible, because proteins interact multitude transferring oscillator information latter. fashion, synchronizes many rhythmic processes.