Best Practices for Conducting Observational Research to Assess the Relation between Nutrition and Bone: An International Working Group Summary

摘要: Diet is a modifiable factor that can affect bone strength and integrity, the risk of fractures. Currently, hierarchy scientific evidence contributes to our understanding role diet on health fracture risk. The generally based type study conducted, quality methodology employed, rigor integrity data collected analysis plan, transparency completeness results. Randomized controlled trials (RCTs) are considered be gold standard from clinical research paradigm, but there dearth high-quality diet-related intervention with as primary outcome, forcing use observational inform practices. However, for most utility, standardization optimization design, accurate reliable measurement key variables, appropriate reporting paramount. Although have been recommendations made in relation RCTs field nutrition, no clear rubric exists best practices conducting regard nutrition health. Therefore, purpose this paper describe considerations designing, conducting, analyzing, interpreting, specifically health, amassed by global panel experts strengths bone, epidemiology, physical activity, public translational trials, methods. represents leadership selected participants 10th annual International Symposium Nutritional Aspects Osteoporosis. topics presented reflect expert opinion areas expertise authors rather than systematic or comprehensive literature review professional guidelines.