Risk of Nonspine Fractures in Older Adults with Sarcopenia, Low Bone Mass, or Both.
作者： Didier Chalhoub , Peggy M Cawthon , Kristine E Ensrud , Marcia L Stefanick , Deborah M Kado
DOI: 10.1111/JGS.13605
关键词:
摘要: Objectives To test the hypothesis that men and women with low bone mineral density (BMD) sarcopenia have a higher risk of fracture than those only one or neither conditions. Design The Osteoporotic Fractures in Men Study are prospective observational studies mean follow up 9 (2000–2012) 8 years (1997–2009), respectively. Setting U.S. clinical centers. Participants Men (n = 5,544; age 73.7) (n = 1,114; 77.6) aged 65 older, able to walk without assistance, bilateral hip replacement. Measurements Sarcopenia was defined as appendicular lean mass plus slowness weakness BMD according World Health Organization definition T-score less –1.0. Participants were classified having normal no (3,367 men, 308 women), (79 48 (1,986 men, 626 (112 132 women). Results Men (hazard ratio (HR)=3.79, 95% confidence interval (CI)=2.65–5.41) (HR=1.67, CI=1.45–1.93) but not (HR=1.14, CI=0.62–2.09) had greater sarcopenia. Women (HR=2.27, CI=1.37–3.76) alone (HR=2.62, CI=1.74–3.95), sarcopenia, sarcopenia. Conclusion Men at especially high fracture. Sarcopenia did increase either group.
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