The accuracy of mRNA—tRNA recognition
作者： R. H. Buckingham , H. Grosjean
DOI: 10.1007/978-94-009-4097-0_5
关键词: Transfer RNA 、 Nonsense mutation 、 Ribosome 、 Amino acid residue 、 Computational biology 、 Mathematics 、 Codon usage bias 、 Polypeptide chain 、 Messenger RNA
摘要: In order to synthesize functional proteins, mRNA must be translated by the ribosome with a certain level of accuracy. As we will discuss below, our knowledge concerning levels precision ultimately attained translational machinery, especially at nascent polypeptide chain, is still incomplete. Furthermore, it interesting compare sparse data that exist results naive calculation following type: in correctly least 50% chains an enzyme as large β-galactosidase which contains 1169 amino acid residues, average error no larger than 1 1700 per residue can tolerated (Fig. 5.1). Why should attaining this accuracy pose problem?
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F. Tamura, S. Nishimura, M. Ohki, The E. coli divE mutation, which differentially inhibits synthesis of certain proteins, is in tRNASer1. The EMBO Journal. ,vol. 3, pp. 1103- 1107 ,(1984) , 10.1002/J.1460-2075.1984.TB01936.X
Hildburg Beier, Miroslawa Barciszewska, Hans-Dieter Sickinger, The molecular basis for the differential translation of TMV RNA in tobacco protoplasts and wheat germ extracts. The EMBO Journal. ,vol. 3, pp. 1091- 1096 ,(1984) , 10.1002/J.1460-2075.1984.TB01934.X
T. Ruusala, M. Ehrenberg, C.G. Kurland, Is there proofreading during polypeptide synthesis The EMBO Journal. ,vol. 1, pp. 741- 745 ,(1982) , 10.1002/J.1460-2075.1982.TB01240.X
F. Bouadloun, D. Donner, C.G. Kurland, Codon-specific missense errors in vivo. The EMBO Journal. ,vol. 2, pp. 1351- 1356 ,(1983) , 10.1002/J.1460-2075.1983.TB01591.X
G. Dirheimer, Chemical nature, properties, location, and physiological and pathological variations of modified nucleosides in tRNAs. Recent results in cancer research. ,vol. 84, pp. 15- 46 ,(1983) , 10.1007/978-3-642-81947-6_2
Structure, function, and genetics of ribosomes New York, NY; Springer-Verlag New York Inc.. ,(1986) , 10.1007/978-1-4612-4884-2
F. Meier, B. Suter, H. Grosjean, G. Keith, E. Kubli, Queuosine modification of the wobble base in tRNAHis influences ‘in vivo’ decoding properties. The EMBO Journal. ,vol. 4, pp. 823- 827 ,(1985) , 10.1002/J.1460-2075.1985.TB03704.X
J Parker, T C Johnston, P T Borgia, G Holtz, E Remaut, W Fiers, Codon usage and mistranslation. In vivo basal level misreading of the MS2 coat protein message. Journal of Biological Chemistry. ,vol. 258, pp. 10007- 10012 ,(1983) , 10.1016/S0021-9258(17)44598-4
Jonathan A. Gallant, Julian E. Davies, Jonathan R Beckwith, Gene function in prokaryotes Cold Spring Harbor Laboratory. ,(1983)
J. E. Celis, J. D. Smith, Nonsense mutations and tRNA suppressors Academic Press. ,(1979)