COMPARATIVE ANALYSIS OF TWO HUMAN CANCER CELL LINES FOLLOWING EXPOSURE TO LOW DOSE RADIATION
作者： Gladys N. Nangami
DOI:
关键词: Cancer research 、 Human melanoma 、 Cancer cell 、 Prostate cancer 、 Low Dose Radiation 、 Biology 、 MAPK/ERK pathway 、 Immunology 、 Dose fractionation 、 Cell culture 、 Cell cycle checkpoint
摘要: Over the past two decades studies on cellular response to very low dose radiation have been revolutionizing historically-held paradigms of radioresponse. Indeed a host seemingly contradictory events recently reported occur within this range exposure which make extrapolation data derived from high these ranges no longer feasible alternative. In study we investigate radioresponse human tumor cell lines A375 melanoma cells and PC3 prostate cancer appear behave quite differently in range. More specifically (a) characterize survival following lines; (b) kinetics magnitude cycle arrest that occurs (c) ascertain whether signaling through MAPK NF-kB proliferative pathways is being stimulated doses radiation. The results demonstrate different responses are seen irradiation (hyper-radioresistance vs. hyper-radiosensitivity cells). Furthermore indicate differential regulation G2/M may be involved observed.
ecu.edu参考文章(158)
Marc Symons, Signaling Pathways Controlled by Rho Family GTP-Binding Proteins Humana Press, Totowa, NJ. pp. 231- 245 ,(2000) , 10.1007/978-1-59259-218-0_13
Adapa V. Prasad, Natarajan Mohan, Bysani Chandrasekar, Martin L. Meltz, Activation of Nuclear Factor κB in Human Lymphoblastoid Cells by Low-Dose Ionizing Radiation Radiation Research. ,vol. 138, pp. 367- 372 ,(1994) , 10.2307/3578685
N. J. Holbrook, Y. Liu, A. J. Fornace, Signaling events controlling the molecular response to genotoxic stress EXS. ,vol. 77, pp. 273- 288 ,(1996) , 10.1007/978-3-0348-9088-5_18
Fred A. Mettler, Warren K. Sinclair, Lynn Anspaugh, Paul B. Selby, Charles Edington, Edward W. Webster, John H. Harley, Harold O. Wyckoff, Robert C. Ricks, The 1986 and 1988 UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation) reports: findings and implications. Health Physics. ,vol. 58, pp. 241- 250 ,(1990) , 10.1097/00004032-199003000-00001
Eric Ho, Jim Woodgett, Mitogen-Activated Protein Kinases Handbook of Cell Signaling (Second Edition). pp. 533- 538 ,(2010) , 10.1016/B978-0-12-374145-5.00071-1
Jacob Falck, Niels Mailand, Randi G. Syljuåsen, Jiri Bartek, Jiri Lukas, The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature. ,vol. 410, pp. 842- 847 ,(2001) , 10.1038/35071124
Natasha Soronika, Igor Filippovitch, Magtouf Gatei, Barbara Weber, Martin F. Lavin, Shaun P. Scott, Kum Kum Khanna, Role for ATM in DNA damage-induced phosphorylation of BRCA1. Cancer Research. ,vol. 60, pp. 3299- 3304 ,(2000)
Gen Yosimichi, Tohru Nakanishi, Takashi Nishida, Takako Hattori, Teruko Takano-Yamamoto, Masaharu Takigawa, CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen‐activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular‐signal regulated kinase (ERK) FEBS Journal. ,vol. 268, pp. 6058- 6065 ,(2001) , 10.1046/J.0014-2956.2001.02553.X
W. G. Mckenna, Hong Bing Zhang, R. J. Muschel, Differential effect of ionizing radiation on the expression of cyclin A and cyclin B in HeLa cells. Cancer Research. ,vol. 53, pp. 1128- 1135 ,(1993)
Ruth J. Muschel, Hong Bing Zhang, George Iliakis, W. Gillies McKenna, Cyclin B expression in HeLa cells during the G2 block induced by ionizing radiation. Cancer Research. ,vol. 51, pp. 5113- 5117 ,(1991) , 10.1016/B978-0-12-168561-4.50651-X