Perlecan inhibits autophagy to maintain muscle homeostasis in mouse soleus muscle.

摘要: The autophagy-lysosome system is essential for muscle protein synthesis and degradation equilibrium, its dysfunction has been linked to various disorders. It reported that a diverse collection of extracellular matrix constituents, including decorin, collagen VI, laminin α2, endorepellin, endostatin, can modulate autophagic signaling pathways. However, the association between autophagy perlecan in homeostasis remains unclear. mechanical unloading perlecan-deficient soleus muscles resulted significantly decreased wet weights cross-section fiber area compared with those control mice. We found deficiency slow-twitch enhanced activity. This was accompanied by decrease substrates, such as p62, an increase LC3II levels. Furthermore, caused reduction phosphorylation levels p70S6k Akt increased AMPKα. Our findings suggested inhibits process through activation mTORC1 pathway. response may be novel target enhancing efficacy skeletal atrophy treatment.