New paradigms in chemokine receptor signal transduction: moving beyond the two-site model
作者： Andrew B. Kleist , Anthony E. Getschman , Joshua J. Ziarek , Amanda M. Nevins , Pierre-Arnaud Gauthier
DOI: 10.1016/J.BCP.2016.04.007
关键词: Chemokine receptor 、 Binding site 、 Chemokine 、 Signal transduction 、 Functional selectivity 、 CCR1 、 Allosteric regulation 、 Bioinformatics 、 Transmembrane domain 、 Neuroscience 、 Biology
摘要: Chemokine receptor (CKR) signaling forms the basis of essential immune cellular functions, and dysregulated CKR underpins numerous disease processes system beyond. CKRs, which belong to seven transmembrane domain (7TMR) superfamily, initiate upon binding endogenous, secreted chemokine ligands. Chemokine-CKR interactions are traditionally described by a two-step/two-site mechanism, in N-terminus recognizes globular core (i.e. site 1 interaction), followed activation when unstructured is inserted into TM bundle 2 interaction). Several recent studies challenge structural independence sites demonstrating physical allosteric links between these supposedly separate sites. Others contest functional sites, identifying nuanced roles for other activation. These developments emerge within rapidly changing landscape influenced PTMs, dimerization, endogenous non-chemokine Simultaneous advances characterization 7TMR biased have altered how we understand promiscuous chemokine-CKR interactions. In this review, explore new paradigms signal transduction considering that depict more intricate architecture governing consequences
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