Joshua J. Ziarek
机构: Associate Professor of Pharmacology, Northwestern University
主页: ziareklab.com
每年引用次数
引用次数
引用: 1,883
H-指数: 22
I10-指数 : 27
出版物: 55
Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4.
M. M. Mysinger , D. R. Weiss , J. J. Ziarek , S. Gravel
Proceedings of the National Academy of Sciences of the United States of America 109 ( 14) 5517 -5522
111
2012
Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways.
L. J. Drury , J. J. Ziarek , S. Gravel , C. T. Veldkamp
Proceedings of the National Academy of Sciences of the United States of America 108 ( 43) 17655 -17660
154
2011
Monomeric CXCL121 peptide and methods of use thereof
Brian Volkman , Joshua Ziarek , Christopher Veldkamp , Francis Peterson
1
2018
CXCL12 Oligomerization Dictates Divergent Signaling and Migratory Responses in Intestinal Epithelial Cells
Luke Drury , Joshua Ziarek , Brian F. Volkman , Michael B. Dwinell
Gastroenterology 140 ( 5) S -645
2011
Engineering nanodiscs for membrane protein studies
Gerhard Wagner , Mahmoud Nasr , Joshua Ziarek , Diego Baptista
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 254
2017
Methods of treating inflammation with monomeric CXCL12 peptide
Brian Volkman , Joshua Ziarek , Christopher Veldkamp , Francis Peterson
2022
Using solution NMR to explore how ligands, G proteins, and arrestins allosterically modulate GPCR conformational dynamics
Joshua Ziarek , Fabian Bumbak , Scott Robson ,
Biophysical Journal 121 ( 3) 429a -429a
2022
Monomeric CXCL121 peptide and methods of treating autoimmune diseases
Brian Volkman , Joshua Ziarek , Christopher Veldkamp , Francis Peterson
2020
Monomeric structure of the cardioprotective chemokine SDF-1/CXCL12
Christopher T. Veldkamp , Joshua J. Ziarek , Jidong Su , Harihar Basnet
Protein Science 18 ( 7) 1359 -1369
70
2009
Examining weak protein–protein interactions in start codon recognition via NMR spectroscopy
Rafael E. Luna , Sabine R. Akabayov , Joshua J. Ziarek , Gerhard Wagner
FEBS Journal 281 ( 8) 1965 -1973
8
2014
New paradigms in chemokine receptor signal transduction: moving beyond the two-site model
Andrew B. Kleist , Anthony E. Getschman , Joshua J. Ziarek , Amanda M. Nevins
Biochemical Pharmacology 114 53 -68
66
2016
Binding site identification and structure determination of protein-ligand complexes by NMR a semiautomated approach.
Joshua J. Ziarek , Francis C. Peterson , Betsy L. Lytle , Brian F. Volkman
Methods in Enzymology 493 241 -275
51
2011
Seasonal adaptations of Daphnia pulicaria swimming behaviour: the effect of water temperature
Joshua J. Ziarek , Ai Nihongi , Takeyoshi Nagai , Marco Uttieri
Hydrobiologia 661 ( 1) 317 -327
23
2011
A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability
Tomonori Takekoshi , Joshua J. Ziarek , Brian F. Volkman , Sam T. Hwang
Molecular Cancer Therapeutics 11 ( 11) 2516 -2525
46
2012
Sulfotyrosine Recognition as Marker for Druggable Sites in the Extracellular Space
Joshua J. Ziarek , Maxime S. Heroux , Christopher T. Veldkamp , Francis C. Peterson
International Journal of Molecular Sciences 12 ( 6) 3740 -3756
12
2011
Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design.
Christopher T. Veldkamp , Joshua J. Ziarek , Francis C. Peterson , Yu Chen
Journal of the American Chemical Society 132 ( 21) 7242 -7243
74
2010
Bicelle size modulates the rate of bacteriorhodopsin folding.
Timothy C. Gruenhagen , Joshua J. Ziarek , Jonathan P. Schlebach
Protein Science 27 ( 6) 1109 -1112
1
2018
Chemokine Cooperativity Is Caused by Competitive Glycosaminoglycan Binding
Folkert Verkaar , Jody van Offenbeek , Miranda M. C. van der Lee , Lambertus H. C. J. van Lith
Journal of Immunology 192 ( 8) 3908 -3914
22
2014
The CXC Chemokine Receptor 4 Ligands Ubiquitin and Stromal Cell-derived Factor-1α Function through Distinct Receptor Interactions
Vikas Saini , Daniel M. Staren , Joshua J. Ziarek , Zayd N. Nashaat
Journal of Biological Chemistry 286 ( 38) 33466 -33477
68
2011
Structural Analysis of a Novel Small Molecule Ligand Bound to the CXCL12 Chemokine
Emmanuel W. Smith , Yan Liu , Anthony E. Getschman , Francis C. Peterson
Journal of Medicinal Chemistry 57 ( 22) 9693 -9699
16
2014