Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design.
作者： Christopher T. Veldkamp , Joshua J. Ziarek , Francis C. Peterson , Yu Chen , Brian F. Volkman
DOI: 10.1021/JA1002263
关键词:
摘要: CXCL12 is an attractive target for clinical therapy because of its involvement in autoimmune diseases, cancer growth, metastasis, and neovascularization. Tyrosine sulfation at three …
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