Impaired extracellular matrix structure resulting from malnutrition in ovariectomized mature rats.
作者： Thaqif El Khassawna , Wolfgang Böcker , Katharina Brodsky , David Weisweiler , Parameswari Govindarajan
DOI: 10.1007/S00418-015-1356-9
关键词: Bone cell 、 Adipogenesis 、 Bone marrow 、 Osteoporosis 、 Bone remodeling 、 Biology 、 Internal medicine 、 Osteoblast 、 Endocrinology 、 Bone resorption 、 Collagen catabolic process
摘要: Bone loss is a symptom related to disease and age, which reflects on bone cells ECM. Discrepant regulation affects cell proliferation ECM localization. Rat model of osteoporosis (OVX) was investigated against control rats (Sham) at young old ages. Biophysical, histological molecular techniques were implemented examine the underlying cellular extracellular matrix changes assess mechanisms contributing in context aging widely used osteoporotic models rats. exhibited compromised function infiltration adipocytes into marrow. However, expression genes regulating collagen catabolic process adipogenesis chronologically shifted diseased comparison with aged bone. The data showed involvement Wnt signaling inhibition due over-expression SOST both Further, OVX animals, an integrin-mediated ERK activation indicated role MAPK osteoblastogenesis adipogenesis. increased PTH levels calcium estrogen deficiency activated osteoblastogenesis. Thusly, RANKL-mediated osteoclastogenesis initiated. Interestingly, show MEPE osteoclast-mediated resorption late stages interplay between change tissue microstructure properties. pathways activating has intriguing similarities oncogenesis myeloma. study indicates importance targeting simultaneously remedy metabolic diseases age-related loss.
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