Individual and combined effects of MDM2 SNP309 and TP53 Arg72Pro on breast cancer risk: an updated meta-analysis
作者： Hongtao Cheng , Biao Ma , Ran Jiang , Wei Wang , Hui Guo
DOI: 10.1007/S11033-012-1800-Z
关键词: Genotype 、 Breast cancer 、 Meta-analysis 、 Mdm2 、 Tumor suppressor gene 、 Bioinformatics 、 Single-nucleotide polymorphism 、 Medicine 、 Confidence interval 、 Odds ratio
摘要: The tumor suppressor gene TP53 and its negative regulator murine double minute 2 are involved in multiple cellular pathways. Two potentially functional single nucleotide polymorphisms (SNPs) MDM2 SNP309 R72P have been extensively investigated to be associated with breast cancer risk. However, the original studies as well subsequent meta-analysis, yielded contradictory results for individual effect of two SNPs on risk, plus that conflicting also existed combined effects This meta-analysis aimed clarify these genes We performed a publications total 9,563 cases 9,468 controls concerning polymorphism 19,748 19,962 R72P. Odds ratios (ORs) 95 % confidence intervals (CIs) were used assess strength association. In overall individuals SNP309TG genotype borderline higher risk than those TT (OR = 1.11, CI: 1.00–1.24, P heterogeneity 0.007), whereas CC or GC had no stratified analyses, significant association between observed Asian, but null found even various subgroups. Moreover, analysis should treated caution, suggested investigations warranted explore molecular mechanism TP53-MDM2 circuit genes.
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sci-hub.se 参考文章(61)
Ali A. Alshatwi, Tarique N. Hasan, Gowhar Shafi, Mohammed A. Alsaif, Amal A. Al-Hazzani, Adulaziz A. Alsaif, A single‐nucleotide polymorphism in the TP53 and MDM‐2 gene modifies breast cancer risk in an ethnic Arab population Fundamental & Clinical Pharmacology. ,vol. 26, pp. 438- 443 ,(2012) , 10.1111/J.1472-8206.2011.00939.X
Sanjay Katiyar Sanjay Katiyar, BK Thelma, NS Murthy, Suresh Hedau Suresh Hedau, Neeraj Jain Neeraj Jain, V Gopalkrishna, SA Husain, BC Das, None, Polymorphism of the p53 codon 72 Arg/Pro and the risk of HPV type 16/18-associated cervical and oral cancer in India. Molecular and Cellular Biochemistry. ,vol. 252, pp. 117- 124 ,(2003) , 10.1023/A:1025546610920
B. Levin, P. Boyle, World Cancer Report 2008 ,(2009)
Nur Buyru, Hatice Tigli, Nejat Dalay, P53 codon 72 polymorphism in breast cancer. Oncology Reports. ,vol. 10, pp. 711- 714 ,(2003) , 10.3892/OR.10.3.711
P. Kleihues, B. W. Stewart, World Cancer Report ,(2003)
Ellen R Copson, Helen E White, Jeremy P Blaydes, David O Robinson, Peter W Johnson, Diana M Eccles, Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers BMC Cancer. ,vol. 6, pp. 80- 80 ,(2006) , 10.1186/1471-2407-6-80
Yan Wan, Wei Wu, Zhihua Yin, Peng Guan, Baosen Zhou, MDM2 SNP309, gene-gene interaction, and tumor susceptibility: an updated meta-analysis BMC Cancer. ,vol. 11, pp. 208- 208 ,(2011) , 10.1186/1471-2407-11-208
Fiona EM Paulin, Mary O'Neill, Gillian McGregor, Andrew Cassidy, Alison Ashfield, Clinton W Ali, Alastair J Munro, Lee Baker, Colin A Purdie, David P Lane, Alastair M Thompson, MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism BMC Cancer. ,vol. 8, pp. 281- 281 ,(2008) , 10.1186/1471-2407-8-281
Woon-Puay Koh, David Van Den Berg, Aizhen Jin, Renwei Wang, Jian-Min Yuan, Mimi C. Yu, Combined effects of MDM2 SNP309 and TP53 R72P polymorphisms, and soy isoflavones on breast cancer risk among Chinese women in Singapore. Breast Cancer Research and Treatment. ,vol. 130, pp. 1011- 1019 ,(2011) , 10.1007/S10549-011-1680-2
Konstantinos P. Economopoulos, Theodoros N. Sergentanis, Differential effects of MDM2 SNP309 polymorphism on breast cancer risk along with race: a meta-analysis Breast Cancer Research and Treatment. ,vol. 120, pp. 211- 216 ,(2010) , 10.1007/S10549-009-0467-1