MDM2 SNP309, gene-gene interaction, and tumor susceptibility: an updated meta-analysis

摘要: The tumor suppressor gene p53 is involved in multiple cellular pathways including apoptosis, transcriptional control, and cell cycle regulation. In the last decade it has been demonstrated that single nucleotide polymorphism (SNP) at codon 72 of associated with risk for development various neoplasms. MDM2 SNP309 a T to G located promoter. From time this well-characterized functional was identified, variety case-control studies have published investigate possible association between cancer risk. However, results studies, as well subsequent meta-analyses, remain contradictory. To whether currently epidemiological can clarify potential interaction genetic variant codon72 (Arg72Pro) mutation status, we performed meta-analysis estimate on 27,813 cases types 30,295 controls. data reviewed indicated homozygote 309GG heterozygote 309TG were significant increased all (homozygote comparison: odds ratio (OR) = 1.25, 95% confidence interval (CI) 1.13-1.37; OR 1.10, CI 1.03-1.17). We also found combination GG Pro/Pro, TG Arg/Arg significantly (OR 3.38, 1.77-6.47; 1.88, 1.26-2.81; 1.96, 1.01-3.78, respectively). stratified analysis by location, brain, liver, stomach uterus 1.47, 1.06-2.03; 2.24, 95%CI 1.57-3.18; 1.54, 1.04-2.29; 1.34, 1.07-1.29, no seen susceptibility status (GG vs TT: 1.17, 0.75-1.82 1.09, 0.89-1.34 positive status; 0.95, 0.72-1.25 1.06, 0.85-1.30 negative status). analyses indicate serves marker, there an Arg72Pro regarding susceptibility. Further take into consideration environmental stresses variants p53-MDM2-related genes are warranted.