Single nucleotide polymorphism 309 affects murin-double-minute 2 protein expression but not glioma tumorigenesis.
作者： Hiromasa TSUIKI , Toru NISHI , Hideo TAKESHIMA , Shigetoshi YANO , Hideo NAKAMURA
DOI: 10.2176/NMC.47.203
关键词:
摘要: Murin-double-minute 2 (MDM2) is an important negative regulator of the p53 tumor suppressor, and affects protein level transcriptional activity. The genotype single nucleotide polymorphism in promoter region MDM2 (single [SNP] 309) associated with expression onset age several types cancer. SNP309 was investigated 254 Japanese patients glioma 50 healthy subjects. frequency T/T homozygous 62 (24%), T/G heterozygous 126 (50%), G/G 66 (26%) patients, similar ratio higher our subjects than Western populations. Immunohistochemical study tissues showed that compared to genotype, suggesting attenuates vivo. However, no association found between histological grade glioma, at disease onset, or gene mutation rate. In population, affected level, but had significant involvement tumorigenesis.
sci-hub.se 参考文章(17)
Martina Schiebe, Petra Ohneseit, Wolfgang Hoffmann, R. Meyermann, Hans-Peter Rodemann, Michael Bamberg, Analysis of mdm2 and p53 gene alterations in glioblastomas and its correlation with clinical factors. Journal of Neuro-oncology. ,vol. 49, pp. 197- 203 ,(2000) , 10.1023/A:1006410702284
Dan Michael, Moshe Oren, The p53 and Mdm2 families in cancer. Current Opinion in Genetics & Development. ,vol. 12, pp. 53- 59 ,(2002) , 10.1016/S0959-437X(01)00264-7
Bert Vogelstein, David Lane, Arnold J. Levine, Surfing the p53 network Nature. ,vol. 408, pp. 307- 310 ,(2000) , 10.1038/35042675
Nicoleta C. Arva, Tamara R. Gopen, Kathryn E. Talbott, Latoya E. Campbell, Agustin Chicas, David E. White, Gareth L. Bond, Arnold J. Levine, Jill Bargonetti, A Chromatin-associated and Transcriptionally Inactive p53-Mdm2 Complex Occurs in mdm2 SNP309 Homozygous Cells Journal of Biological Chemistry. ,vol. 280, pp. 26776- 26787 ,(2005) , 10.1074/JBC.M505203200
Hirofumi Nakanishi, Yasuhiko Tomita, Hideki Yoshikawa, Noriko Sato, Takahiro Ochi, Katsuyuki Aozasa, Frequentp53Gene Mutations in Soft Tissue Sarcomas Arising in Burn Scar Japanese Journal of Cancer Research. ,vol. 90, pp. 276- 279 ,(1999) , 10.1111/J.1349-7006.1999.TB00744.X
Yukitaka Ushio, Correlation of molecular genetic analysis of P53 MDM2 P16 PTEN and EGFR and survival of patients with anaplastic astrocytoma and glioblastoma Frontiers in Bioscience. ,vol. 8, pp. e281- 288 ,(2003) , 10.2741/865
Hiroko Ohgaki, Paul Kleihues, Epidemiology and etiology of gliomas Acta Neuropathologica. ,vol. 109, pp. 93- 108 ,(2005) , 10.1007/S00401-005-0991-Y
Hongxia Ma, Zhibin Hu, Xiangjun Zhai, Shui Wang, Xuechen Wang, Jianwei Qin, Guangfu Jin, Jiyong Liu, Xinru Wang, Qingyi Wei, Hongbing Shen, Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population Cancer Letters. ,vol. 240, pp. 261- 267 ,(2006) , 10.1016/J.CANLET.2005.09.019
Pia Alhopuro, SK Ylisaukko-Oja, WJ Koskinen, Petri Bono, Johanna Arola, Heikki J Järvinen, Jukka-Pekka Mecklin, Timo Atula, Risto Kontio, AA Mäkitie, Sinikka Suominen, Ilmo Leivo, Pia Vahteristo, Leena-Maija Aaltonen, Lauri A Aaltonen, The MDM2 promoter polymorphism SNP309T→G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck Journal of Medical Genetics. ,vol. 42, pp. 694- 698 ,(2005) , 10.1136/JMG.2005.031260
Shoji Shiraishi, Kenji Tada, Hideo Nakamura, Keishi Makino, Masato Kochi, Hideyuki Saya, Jun‐ichi Kuratsu, Yukitaka Ushio, None, Influence of p53 mutations on prognosis of patients with glioblastoma. Cancer. ,vol. 95, pp. 249- 257 ,(2002) , 10.1002/CNCR.10677